The Mectizan® Donation Program – highlights from 2005
نویسندگان
چکیده
Through the Mectizan Donation Program, Merck & Co., Inc. has donated Mectizan (ivermectin, MSD) for the treatment of onchocerciasis worldwide since 1987. Mectizan has also been donated for the elimination of lymphatic filariasis (LF) since 1998 in African countries and in Yemen where onchocerciasis and LF are co-endemic; for LF elimination programs, Mectizan is co-administered with albendazole, which is donated by GlaxoSmithKline. The Mectizan Donation Program works in collaboration with the Mectizan Expert Committee/Albendazole Coordination, its scientific advisory committee. In 2005, a total of 62,201,310 treatments of Mectizan for onchocerciasis were approved for delivery via mass treatment programs in Africa, Latin America, and Yemen. Seventy-seven percent and 20% of these treatments for onchocerciasis were for countries included in the African Programme for Onchocerciasis Control (APOC) and the former-Onchocerciasis Control Programme in West Africa (OCP), respectively. The remaining 3% of treatments approved were for the six onchocerciasis endemic countries in Latin America, where mass treatment is carried out twice-yearly with the goal of completely eliminating morbidity and eventually transmission of infection, and for Yemen. All 33 onchocerciasis endemic countries where mass treatment with Mectizan is indicated have ongoing mass treatment programs. In 2005, 42,052,583 treatments of co-administered albendazole and Mectizan were approved for national Programs to Eliminate LF (PELFs) in Africa and Yemen. There are ongoing PELFs using albendazole and Mectizan in nine African countries and Yemen; these represent 35% of the total number of countries expected to require the co-administration of these two chemotherapeutic agents for LF elimination. In Africa, the expansion of existing PELFs and the initiation of new ones have been hampered by lack of resources, technical difficulties with the mapping of LF endemicity, and the co-endemicity of LF and loiasis. Included in this review are recommendations recently put forward for the co-administration of albendazole and Mectizan in areas endemic for LF, loiasis, and onchocerciasis.
منابع مشابه
Operational lessons from 20 years of the Mectizan Donation Program for the control of onchocerciasis.
The donation of ivermectin (Mectizan, Merck & Co., Inc.) to control onchocerciasis (river blindness) was established in 1987 and has since gradually expanded to provide for >570 million treatments cumulatively over the past 20 years. The Mectizan Donation Program (MDP) operates within a broad partnership in 33 endemic countries in need of mass treatment. Particular operational methods and tools...
متن کاملThe case of ivermectin: lessons and implications for improving access to care and treatment in developing countries.
On October 21, 1987, Merck & Co., Inc., announced plans to donate Mectizan (ivermectin), a new medicine designed to combat onchocerciasis (Ôriver blindnessÕ), for as long as it might be needed. Merck took this action, working in col laboration with international experts in parasitology, the World Health Organization, and other agencies to reach those affected by the illness. This unusual decisi...
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The Mectizan Donation Program (MDP) was established in 1987 to oversee Merck’s donation of Mectizan (ivermectin, MSD) for the control of onchocerciasis (river blindness) worldwide [1]. This was accelerated and expanded when Merck made a groundbreaking announcement in 1987: it would donate ivermectin, completely free of charge, as much as needed and for as long as needed, for the elimination of ...
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1 Mectizan Donation Program, Decatur, Georgia, United States of America, 2 Ministère de la Sante, Lomé, Togo, 3 Faculté Mixte de Médecine et de Pharmacie, Université de Lomé, Lomé, Togo, 4 Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America, 5 HDI (Health & Development International), Fjellstrand, Norway, 6 Division of Paras...
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The occurrence of Serious Adverse Experiences (SAEs) following Mectizan(R) treatment of onchocerciasis in Loa loa endemic areas has been increasingly reported over the past decade. These SAEs include a severely disabling, and potentially fatal, encephalopathy, which appears to correlate with a high load of L. loa microfilariae (> 30,000 mf/ml).Previous consultations organized by the Mectizan(R)...
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ورودعنوان ژورنال:
- Filaria Journal
دوره 5 شماره
صفحات -
تاریخ انتشار 2006